Prostate Cancer Detection by Serum Proteomic Profiling

• The goal of this research is to use novel proteomic technologies to develop new blood tests to help detect prostate cancer at an early curable stage and to reduce the number of unnecessary biopsies.
• This trial involves giving a blood sample prior to surgery and then 6 weeks or 3 months following surgery.
• All men undergoing robotic radical prostatectomy for localized prostate cancer are eligible to participate.

Molecular Urine Tests for Prostate Cancer

• The goal of this trial is to evaluate the accuracy of an existing urine-based test for prostate cancer detection.
• This trial involves:
• Pre-operative voided urine collection following digital exam
• During time of surgery, collection of urine from foley catheter
• Collection of urine from foley just prior to removal 6 – 8 days after surgery.
• Voided urine specimen 3 months following surgery.
• All men undergoing robotic radical prostatectomy for localized prostate cancer are eligible to participate.

Predictive Signatures for Prostate Cancer

• The goal of this trial is to find gene expression signatures that are associated with invasive prostate cancer.
• This trial involves allowing our research team to use some of the prostate tissue that has been removed during the normal process of radical prostatectomy. The prostate cancer cells will be extracted and gene expression analysis performed. The results of this analysis will be correlated with clinical outcome. Since, only a relatively small amount of tissue is used for this research project it will not compromise the normal pathologic assessment of the prostate.
• All men undergoing robotic radical prostatectomy for localized prostate cancer are eligible to participate.

Contribution of Periprostatic Adipose Tissue To Prostate Cancer Aggressiveness

• There is now substantial evidence that obesity is associated with more aggressive prostate cancer. The purpose of this study is to investigate the role that fat plays in promoting prostate cancer growth.
• This trial involves allowing our research team to use the fat surrounding the prostate, tissue that is removed as part of standard robotic prostatectomy, for research studies in our laboratory. The results of the laboratory analysis will be compared with clinical outcome.
• All men undergoing robotic radical prostatectomy for localized prostate cancer are eligible to participate.